In vitroandin vivoantitumor activity of the halogenated boroxine dipotassium-trioxohydroxytetrafluorotriborate (K2[B3O3F4OH])
| Autor: | Maja Marasović, Ranko Stojković, Siniša Ivanković, Mladen Miloš, Borivoj Galic, Jelena Ostojić, Zoran Galić |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Boron Compounds
Halogenation Antineoplastic Agents Biology Pharmacology Mice Structure-Activity Relationship chemistry.chemical_compound In vivo Cell Line Tumor Drug Discovery medicine Animals Structure–activity relationship Cytotoxic T cell Cell Proliferation Mice Inbred BALB C Mice Inbred C3H Dose-Response Relationship Drug Molecular Structure Cell growth Cancer General Medicine medicine.disease Boroxine In vitro Mice Inbred C57BL chemistry Cancer cell Drug Screening Assays Antitumor Antitumor activity drug research halogenated boroxine |
| Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry. 30:354-359 |
| ISSN: | 1475-6374 1475-6366 |
| DOI: | 10.3109/14756366.2014.926344 |
| Popis: | Dipotassium-trioxohydroxytetrafluorotriborate K2[B3O3F4OH] was listed as a promising new therapeutic for cancer diseases. For in vitro and in vivo investigation of its antitumor effects 4T1 mammary adenocarcinoma, B16F10 melanoma and squamous cell carcinoma SCCVII were used. The detailed in vitro investigation undoubtedly showed that K2[B3O3F4OH] affects the growth of cancer cells. The proliferation of cells depends on the concentration so that aqueous solution of K2[B3O3F4OH], the concentrations of 10(-4) M and less, does not affect cell growth, but the concentrations of 10(-3) M or more, significantly slows cells growth. B16F10 and SCCVII cells show higher sensitivity to the cytotoxic effects of K2[B3O3F4OH] compared to 4T1 cells. Under in vivo conditions, K2[B3O3F4OH] slows the growth of all three tumors tested compared to the control, and the inhibitory effect was most pronounced during the application of the substance. There is almost no difference if K2[B3O3F4OH] was applied intraperitoneally, intratumor, peroral or as ointment. Addition of 5-FU did not further increase the antitumor efficacy of K2[B3O3F4OH]. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|