Serologic markers of autoimmunity in women with polycystic ovary syndrome
| Autor: | Katharina Walch, Clemens B. Tempfer, Lukas Hefler, Wolfgang Huebl, Konstantin Baumuehlner, Katrin Hefler-Frischmuth |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Anti-nuclear antibody Autoimmunity medicine.disease_cause Autoimmune Diseases Serology Histones Young Adult Internal medicine Antinucleosome antibodies Humans Medicine Serologic Tests medicine.diagnostic_test biology business.industry Autoantibody Obstetrics and Gynecology DNA Polycystic ovary Nucleosomes Endocrinology Reproductive Medicine Antibodies Antinuclear Case-Control Studies Immunoglobulin G Immunoassay biology.protein Female Antibody business Biomarkers Polycystic Ovary Syndrome |
| Zdroj: | Fertility and Sterility. 93:2291-2294 |
| ISSN: | 0015-0282 |
| Popis: | Objective To evaluate whether women with the polycystic ovary syndrome (PCOS) have an increased rate of elevated serum levels of common autoimmunologic parameters. Design Prospective case-control study. Setting Academic research institution. Patient(s) One hundred nine women with PCOS and 109 age-matched healthy controls. Intervention(s) Peripheral venous puncture, ultrasonography, questionnaire. Main Outcome Measure(s) Serum levels of antinuclear antibodies (ANAs) were measured by immunometric enzyme immunoassay, serum levels of IgG class autoantibodies against histone, IgG class autoantibodies against nucleosomes, and IgG class autoantibodies against double-stranded (ds) DNA were measured by enzyme immunoassays. Result(s) Women with PCOS had significantly elevated serum levels of antihistone and anti-dsDNA antibodies, whereas serum levels of ANAs and antinucleosome antibodies were similar between the two groups. When serum levels of ANAs, antihistone, antinucleosomes, and anti-dsDNA antibodies were correlated with clinical and biochemical parameters, a significant correlation between serum levels of ANAs and serum TSH was established. Conclusion(s) Our study shows that serologic parameters of autoimmunity (i.e., antihistone and anti-dsDNA antibodies) are elevated in women with PCOS. A role of autoimmunologic processes in PCOS can be suspected. |
| Databáze: | OpenAIRE |
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