Prussian blue decorated mesoporous silica hybrid nanocarriers for photoacoustic imaging-guided synergistic chemo-photothermal combination therapy
| Autor: | Hyehyun Kim, Vy Phan Thi Tuong, Nhat Quang Bui, Junghwan Oh, Manivasagan Panchanathan, Madhappan Santha Moorthy, Bharathiraja Subramanian, Sudip Mondal, Giang Hoang |
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| Rok vydání: | 2020 |
| Předmět: |
Prussian blue
Materials science Combination therapy technology industry and agriculture Biomedical Engineering Nanoparticle Nanotechnology 02 engineering and technology General Chemistry General Medicine Photothermal therapy Mesoporous silica 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry In vivo Drug delivery General Materials Science Nanocarriers 0210 nano-technology |
| Zdroj: | Journal of materials chemistry. B. 6(32) |
| ISSN: | 2050-7518 |
| Popis: | The fabrication of nanotherapeutic systems capable of stimuli-responsive drug delivery and photoacoustic imaging (PAI)-guided photothermal therapy (PTT) is considered significant for chemo-photothermal therapy applications in cancer therapy. In the present study, the Prussian blue nanoflake (PBNF) decorated mesoporous silica hybrid nanoparticle (PB@MSH-EDA NPs) is reported for PAI-guided chemo-photothermal therapy applications. The amine group enriched mesoporous silica channels can be used to encapsulate an anticancer drug for chemotherapy, and the surface decorated PBNFs can convert a near-infrared (NIR) laser (808 nm) into heat for photothermal therapy and can also be used for PAI applications. The PB@MSH-EDA NPs show pH-responsive drug release efficiency under acidic pH (pH 5.0 and 4.0) conditions. Furthermore, the PB@MSH-EDA NPs system shows strong NIR laser absorption and photothermal conversion efficiency under 808 nm laser irradiation. The in vitro experimental result shows that the PB@MSH-EDA NPs are biocompatible and could be efficiently taken up by MDA-MB-231 cells. In addition, the in vivo results demonstrate that the tumor-bearing mice fully recovered after injecting the drug (Dox)-loaded PB@MSH-EDA/Dox NPs and being further irradiated with the 808 nm laser. We believe that the PB@MSH-EDA NPs system could be utilized as an efficient PAI-guided chemo-photothermal therapy agent for the detection and treatment of tumors in an emerging cancer therapy application. |
| Databáze: | OpenAIRE |
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