Anxiolytic and Antidepressant Effects of Divaza and Brizantin
| Autor: | O. I. Epshtein, Molodavkin Gm, V. I. Poseva, M. A. Putilovskii, V. V. Andreeva, I. A. Ertuzun, Yu. L. Dugina, N. I. Suslov, N. N. Yakovleva, T. A. Voronina |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.drug_class Drug Evaluation Preclinical Pharmacology Motor Activity Anxiolytic General Biochemistry Genetics and Molecular Biology Antibodies Vogel Conflict Test Medicine Animals Motor activity Maze Learning Swimming Diazepam Behavior Animal Test procedures business.industry Brain General Medicine Antidepressive Agents Rats Drug Combinations Anti-Anxiety Agents Antidepressant Emotional behavior business Stress Psychological medicine.drug Behavioural despair test |
| Zdroj: | Bulletin of experimental biology and medicine. 159(6) |
| ISSN: | 1573-8221 |
| Popis: | The anxiolytic and antidepressant activities of complex preparations divaza and brizantin containing antibodies to brain-specific protein S100 were estimated using Vogel conflict test and Nomura forced swimming test. Course treatment (5 days) of brizantin in a dose of 2.5 ml/kg and divaza in a dose of 7.5 ml/kg significantly increased punished drinking in the Vogel conflict test in comparison with the control. Both drugs also improved general emotional behavior during training prior to the test procedure. Brizantin and divaza in a dose of 7.5 ml/kg increased the number of wheel revolutions in the Nomura forced swimming test in comparison with the control; the effect of divaza was more pronounced. High correlation coefficients between the number of wheel revolutions during the first and second 5-min sessions are also indicative of antidepressant action of divaza and brizantin. |
| Databáze: | OpenAIRE |
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