Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury
| Autor: | Masahiko Kawaguchi, Hitoshi Furuya, Noboru Konishi, Keiji Shimada, Masahiro Takahashi, Toshikatsu Nakashima |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Indomethacin Rats Sprague-Dawley Lesion Indometacin Physical Stimulation medicine Animals Pain Measurement Lumbar Vertebrae biology business.industry General Neuroscience Axotomy Nerve injury medicine.disease Sciatic Nerve Rats Disease Models Animal Spinal Nerves Peripheral neuropathy Allodynia Touch Anesthesia Spinal nerve Neuropathic pain biology.protein Cyclooxygenase medicine.symptom business medicine.drug |
| Zdroj: | Neuroscience Letters. 356:37-40 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2003.11.017 |
| Popis: | To clarify the role of cyclooxygenase in the peripheral nerve on the development of neuropathic pain, we investigated the effects of peri-sciatic administration of indomethacin on the development of allodynia in a model of L5 single spinal nerve injury. Peri-sciatic administration of indomethacin (1 mg/kg) was performed 3, 24, or 72 h after nerve injury (n=6/each). In rats with indomethacin 3 or 24 h after nerve injury, ipsi-lateral paw withdrawal thresholds 7-35 days after nerve injury were significantly higher compared with those in the control group (n=6: without peri-sciatic treatment) (P0.05). However, such efficacy was no longer apparent when indomethacin was administered 72 h after nerve injury. These results suggest that peri-sciatic administration of indomethacin early (less than 24 h) after nerve injury can attenuate the development of allodynia. |
| Databáze: | OpenAIRE |
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