The pharmacokinetics of a single rectal dose of paracetamol (40 mg.kg-1) in children with liver disease
| Autor: | C R H, Cormack, S, Sudan, R, Addison, J, Keating, R A, Sherwood, E M C, Ashley, Tanya, Howell |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Cmax Biological Availability Anesthesia General Suppository Chronic liver disease Gastroenterology Loading dose Liver Function Tests Pharmacokinetics Administration Rectal Internal medicine Humans Medicine International Normalized Ratio Child Acetaminophen Biologic marker medicine.diagnostic_test business.industry Liver Diseases Analgesics Non-Narcotic medicine.disease Anesthesiology and Pain Medicine Child Preschool Anesthesia Chronic Disease Pediatrics Perinatology and Child Health Female business Liver function tests medicine.drug |
| Zdroj: | Pediatric Anesthesia. 16:417-423 |
| ISSN: | 1460-9592 1155-5645 |
| Popis: | Summary Background: The aim of our study was to measure the serum paracetamol concentrations achieved following a single rectal loading dose of 40 mg·kg−1 in children with chronic liver disease. Methods: We recruited 17 children (3–15 years, 10.6–75 kg) undergoing minor surgical procedures under general anesthesia. Paracetamol was administered at the end of surgery and blood samples were taken for analysis at 2, 3, 4, 6 and 8 h postdose. Results: The mean Cmax of 11.4 mg·l−1 [coefficient of variation (CV) 66%] was achieved at a Tmax of 2.7 h (CV 42%). The relative bioavailability (F) of the suppository formulation was not estimated, but clearance (Cl/F) estimates 0.73 l·kg−1·h−1 (CV 87%) and time–concentration profiles for these children were similar to the normal pediatric population. Conclusions: There are currently no biologic markers available for monitoring possible hepatotoxicity in this cohort of patients with liver disease, but our data suggest that a single-dose suppository is a satisfactory analgesic alternative. |
| Databáze: | OpenAIRE |
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