Prognostic utility of the 2011 GOLD classification and other multidimensional tools in Asian COPD patients: a prospective cohort study
| Autor: | Xue Yun Wong, Venetia Ong, Sally Chin, Pauline Lee Poh Chong, Hiang Ping Chan, Yiong Huak Chan, Jason Phua, Tow Keang Lim, Amartya Mukhopadhyay |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Copd patients morbidity International Journal of Chronic Obstructive Pulmonary Disease Cohort Studies Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Asian People Internal medicine Humans COPD Medicine Prospective Studies 030212 general & internal medicine Prospective cohort study Aged Original Research business.industry General Medicine Guideline Prognosis medicine.disease mortality Obstructive lung disease respiratory tract diseases 030228 respiratory system Disease Progression Physical therapy Female business Gold classification guideline |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| Popis: | Hiang Ping Chan,1,2 Amartya Mukhopadhyay,1,2 Pauline Lee Poh Chong,1,2 Sally Chin,1,2 Xue Yun Wong,1,2 Venetia Ong,1,2 Yiong Huak Chan,3 Tow Keang Lim,1,2 Jason Phua1,2 1Division of Respiratory and Critical Care Medicine, University Medicine Cluster, National University Health System, 2Department of Medicine, 3Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Background: How well the 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification prognosticates for Asian patients with COPD is unknown.Objective: The authors aimed to study the predictive utility of the GOLD 2011 classification for exacerbations and mortality as compared with other multidimensional tools in an Asian population.Methods: In all, 1,110 COPD patients were prospectively followed between March 2008 and March 2013. They were classified using the 2011 and 2007 GOLD guidelines, modified Medical Research Council score, St. George’s Respiratory Questionnaire (SGRQ), and Body mass index, Obstruction, Dyspnea (BOD) index. Outcome measures were exacerbations and mortality. Multivariable survival analyses and receiver operating characteristic (ROC) curves were used to assess the different classification systems.Results: Time-to-event analyses demonstrated earlier exacerbations in 2011’s GOLD D when compared with GOLD A (hazard ratio [HR] 0.54, 95% confidence interval [CI]: 0.31–0.95, P=0.032) and GOLD B (HR 0.62, 95% CI: 0.45–0.85, P=0.003) and higher mortality when compared with GOLD A (HR 0.37, 95% CI: 0.16–0.88, P=0.025) and GOLD B (HR 0.46, 95% CI: 0.31–0.70, P0.05).Conclusion: The 2011 GOLD classification predicts exacerbations and mortality moderately well in Asian COPD patients. Its prognostic utility is similar to that of other multidimensional systems. Keywords: COPD, guideline, morbidity, mortality, prognosis |
| Databáze: | OpenAIRE |
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