Multichannel Front-End for Electrochemical Sensing of Metabolites, Drugs, and Electrolytes
| Autor: | Nadezda Pankratova, Giovanni De Micheli, Francesca Criscuolo, Sandro Carrara, Ivan Ny Hanitra |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
010401 analytical chemistry Analytical chemistry Linearity chemistry.chemical_element Electrolyte Sense (electronics) Electrochemistry 01 natural sciences 0104 chemical sciences chemistry Voltage sensing Lithium Sensitivity (control systems) Electrical and Electronic Engineering Instrumentation Order of magnitude |
| Zdroj: | IEEE Sensors Journal |
| ISSN: | 1530-437X |
| DOI: | 10.1109/jsen.2019.2959885 |
| Popis: | A multi-channel front-end for electrochemical sensing is presented. It consists of a multiplexed four-channel readout interface supporting amperometric, voltammetric, and potentiometric measurements. The electronic interface is co-designed according to the target biomarker specifications, and exhibits excellent linearity in both current and voltage sensing. The sensing front-end is characterized with lactate, paracetamol, and lithium sensing, yielding sensitivity of ${1.2} \pm {0.3}\, \mu {A}/\textit {mM}$ , ${69.6} \pm {2}\, \textit {nA}/\mu {M}$ , and ${55.6}\,\textit {mV}/\textit {decade}$ , respectively. These performances are comparable with the ones obtained with a bulky commercial Autolab potentiostat. Moreover, the limit of detection achieved are of ${37}\pm {8}\,\mu {M}$ , ${2.1}\pm {1.22}\,\mu {M}$ , and ${11}\pm {3.5}\,\mu {M}$ , respectively, for the aforementioned sensors. These values are more than one order of magnitude lower than the relevant detection range. This successful characterization demonstrates the ability of the proposed system to monitor, in a broader sense, metabolites, drugs, and electrolytes. The programmability, versatility and portability of the front-end interface paves the way for a continuous monitoring of different families of biomarkers, suitable for advanced healthcare diagnosis and wearable physiology. |
| Databáze: | OpenAIRE |
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