Circulation of Bordetella pertussis in the Caribbean Netherlands: a population-based seroepidemiological study
| Autor: | Eric R.A. Vos, Alcira V.A. Janga-Jansen, Jeffrey van Vliet, Gerco den Hartog, Hester E. de Melker, Fiona R. M. van der Klis, Maarten M. Immink, Koen Hulshof, Nicoline A.T. van der Maas, Sharda Baboe-Kalpoe, Jeroen Kerkhof |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Microbiology (medical) Bordetella pertussis medicine.medical_specialty Adolescent Infectious and parasitic diseases RC109-216 Logistic regression Young Adult Seroepidemiologic Studies Internal medicine medicine Humans Child Pertussis Vaccine Disease surveillance biology Transmission (medicine) business.industry Risk of infection pertussis Caribbean Netherlands General Medicine biology.organism_classification vaccination Antibodies Bacterial Vaccination Infectious Diseases Infectious disease (medical specialty) circulation seroepidemiology business |
| Zdroj: | International Journal of Infectious Diseases, Vol 111, Iss, Pp 21-27 (2021) |
| Popis: | Objectives Pertussis is a respiratory infectious disease caused by Bordetella pertussis. In the Caribbean Netherlands (CN), comprising the islands Bonaire, St Eustatius, and Saba, registration of cases is mandatory for disease surveillance. However, insufficient laboratory facilities hamper case confirmation, and circulation persists. The aim of this seroepidemiological study was to gain insight into B. pertussis circulation in CN, and to investigate what factors contribute to the risk of infection. Methods Blood samples and questionnaires were collected for 1829 participants aged 0–90 years. Concentrations of B. pertussis toxin-specific IgG antibodies (anti-Pt) were determined using a bead-based immunoassay to indicate infections within the previous 12 months (based on anti-Pt ≥ 50 IU/mL) in participants without detectable vaccine-induced humoral immunity. Risk factors for recent infection were analyzed using logistic regression models. Results An estimated 8.2% (95% CI 6.6–10.1) of CN residents aged ≥ 9 years were found to have been recently infected by B. pertussis. Risk factors for a recent infection were age 12–29 years (13.8–14.6%) and Dutch Caribbean or Surinamese origin (10.7%). Conclusions B. pertussis infections occur frequently among CN residents aged ≥ 9 years, although few clinical pertussis cases are reported. Transmission to vulnerable individuals seems likely and should be taken into account in optimizing vaccination programs. |
| Databáze: | OpenAIRE |
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