Pediatric-Onset Multiple Sclerosis: A Single Center Study
| Autor: | Matthew R. Ginsberg, Erin Yamamoto, Mary Rensel, Manikum Moodley |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Multiple Sclerosis Adolescent Single Center vitamin D deficiency Young Adult 03 medical and health sciences 0302 clinical medicine Neuroimaging Prevalence medicine Humans 030212 general & internal medicine Age of Onset Young adult Child Retrospective Studies medicine.diagnostic_test business.industry Multiple sclerosis Retrospective cohort study Magnetic resonance imaging medicine.disease Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health Female Neurology (clinical) Age of onset business Biomarkers 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of Child Neurology. 33:98-105 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/0883073817739789 |
| Popis: | Pediatric-onset multiple sclerosis (POMS), once thought to be rare, is now being diagnosed in increasing numbers in children. Despite improvements to diagnostic criteria, the diagnosis and management of POMS remains challenging. The aim of this study is to retrospectively describe a growing POMS patient population seen at a single center over a 13 year period. Epidemiologic, clinical, neuroimaging, laboratory features and therapeutic management and outcome data were collected and analyzed. These data support associations between MS and environmental triggers such as obesity and vitamin D deficiency. Presenting symptoms, magnetic resonance imaging and laboratory findings were consistent with the existing literature; however, the prevalence of cortical lesions and abnormal saccadic pursuit is higher than other reports. Data also demonstrate a shift in practice from first- to second-line therapies over the observed period. |
| Databáze: | OpenAIRE |
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