Prognostic factors of nasopharynx tumors investigated by MR imaging and the value of MR imaging in the newly published TNM staging
| Autor: | Hisayasu Nagakura, Koh-ichi Sakata, Kazumitsu Koito, M. Tamakawa, Tetsuo Himi, Mitsuo Sido, Hidenari Akiba, Kohji Asakura, Masato Hareyama, Atushi Oouchi |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Cancer Research Adolescent medicine.medical_treatment otorhinolaryngologic diseases medicine Parapharyngeal space Humans Radiology Nuclear Medicine and imaging Radiation treatment planning Aged Neoplasm Staging Radiation medicine.diagnostic_test business.industry Cancer Soft tissue Nasopharyngeal Neoplasms Magnetic resonance imaging Middle Aged Prognosis medicine.disease Magnetic Resonance Imaging Primary tumor Radiation therapy Oncology Nasopharyngeal carcinoma Lymphatic Metastasis Female Tomography X-Ray Computed business Nuclear medicine Follow-Up Studies |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 43:273-278 |
| ISSN: | 0360-3016 |
| Popis: | Purpose: To examine the usefulness of MR imaging for predicting local control of nasopharyngeal carcinoma (NPC) and the value of MR imaging in the newly published fifth edition of the TNM classification. Methods and Materials: We studied 29 patients with NPC with MR imaging and CT before and after treatment. Staging was done according to the fourth and newly published fifth editions of the International Union Against Cancer (UICC) staging system. The radiotherapy protocol was designed to deliver 66 to 68 Gy to the primary tumor and clinically involved nodes. Results: MR proved better than CT at identifying obliteration of the pharyngobasilar fascia, invasion of the sinus of Morgagni, through which the cartilaginous portion of the eustachian tube and the levator veli palatini muscle pass, invasion of the skull base, and metastases to lymph nodes in the carotid and retropharyngeal spaces. All seven patients without invasion of the pharyngobasilar fascia had local control. The local control rates of patients with invasion of the skull base were not good (60 to 73%). There was no apparent relationship between tumor volume determined by T1-weighted MR images and local control when the tumor volume was more than 20 cc. The newly published N staging system appears to successfully identify the high-risk group for distant metastasis as N3. In our series, four of five patients with N3 disease developed distant metastases. Conclusion: Deep infiltration of the tumor is a more important prognostic factor in NPC than tumor volume. Since the newly published T staging system requires a search for tumor invasion into soft tissue such as parapharyngeal space and bony structures, MR imaging may be indispensable for the newly published NPC staging system. |
| Databáze: | OpenAIRE |
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