Cannabinoid Type 1 Receptor Antagonism Delays Ascites Formation in Rats With Cirrhosis
| Autor: | Marco Domenicali, Paolo Caraceni, A. Principe, T. Croci, Franco Trevisani, Ferdinando Giannone, Andrea Zambruni, Anna Maria Pertosa, Mauro Bernardi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Cirrhosis Natriuresis Diuresis Blood Pressure Kidney Liver Cirrhosis Experimental Renal Circulation Piperidines Receptor Cannabinoid CB1 Internal medicine Ascites medicine Animals Cardiac Output Rats Wistar Carbon Tetrachloride Renal circulation Dose-Response Relationship Drug Hepatology business.industry Sodium Gastroenterology Sodium Dietary medicine.disease Rats medicine.anatomical_structure Endocrinology Renal sodium excretion Renal blood flow Pyrazoles Vascular Resistance Rimonabant medicine.symptom business |
| Zdroj: | Gastroenterology. 137:341-349 |
| ISSN: | 0016-5085 |
| DOI: | 10.1053/j.gastro.2009.01.004 |
| Popis: | Endocannabinoids contribute to hemodynamic abnormalities of cirrhosis. Whether this favors renal sodium retention and ascites formation is unknown. We determined whether cannabinoid type 1 receptor antagonism prevents sodium retention and ascites formation in preascitic cirrhotic rats.Once renal sodium handling was impaired, rats with carbon tetrachloride-induced cirrhosis were randomized to receive either vehicle or rimonabant (3 [group 1] or 10 [group 2] mg x kg(-1) x day(-1)) for 2 weeks. Natriuresis, sodium intake, and sodium balance were measured daily. At the end of the protocol, systemic hemodynamics, renal blood flow, ascites volume, and liver fibrosis were assessed.A significant reduction in ascites formation (group 1: 54%; group 2: 10%; vehicle: 90%) and volume (group 1: 1.6 +/- 0.3 mL; group 2: 0.5 mL; vehicle: 5.5 +/- 0.8 mL) occurred in treated rats. Rimonabant significantly improved sodium balance during week 2 (group 1: 0.98 +/- 0.08 mmol; group 2: 0.7 +/- 0.08 mmol; vehicle: 3.05 +/- 0.11 mmol). Both treated groups showed lower cardiac output and higher mean arterial pressure, peripheral vascular resistance, and renal blood flow (P.05). Liver fibrosis was reduced in group 2 by 30% (P.05 vs vehicle). Mean arterial pressure inversely correlated with sodium balance (R = -0.61; P = .003), but not with fibrosis score.Rimonabant improves sodium balance and delays decompensation in preascitic cirrhosis. This is achieved though an improvement in systemic and renal hemodynamics, although it cannot be excluded that the antifibrotic effect of the drug may play a role. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|