Immune response during hantavirus diseases: implications for immunotherapies and vaccine design
| Autor: | Fabián E. Díaz, Farides Saavedra, Alexis M. Kalergis, Angello Retamal-Díaz, Camila Covián, Pablo A. González |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Orthohantavirus Inflammatory response animal diseases Hantavirus Infections Immunology Disease Viral Zoonoses Food and drug administration Mice Immune system Case fatality rate Immunology and Allergy Medicine Animals Humans Haemorrhagic fever Review Articles Hantavirus Immunity Cellular business.industry Public health virus diseases Viral Vaccines Heart Arrest Hemorrhagic Fever with Renal Syndrome business |
| Zdroj: | Immunology |
| Popis: | Orthohantaviruses, previously named hantaviruses, cause two emerging zoonotic diseases: haemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Overall, over 200 000 cases are registered every year worldwide, with a fatality rate ranging between 0·1% and 15% for HFRS and between 20% and 40% for HCPS. No specific treatment or vaccines have been approved by the U.S. Food and Drug Administration (FDA) to treat or prevent hantavirus-caused syndromes. Currently, little is known about the mechanisms at the basis of hantavirus-induced disease. However, it has been hypothesized that an excessive inflammatory response plays an essential role in the course of the disease. Furthermore, the contributions of the cellular immune response to either viral clearance or pathology have not been fully elucidated. This article discusses recent findings relative to the immune responses elicited to hantaviruses in subjects suffering HFRS or HCPS, highlighting the similarities and differences between these two clinical diseases. Also, we summarize the most recent data about the cellular immune response that could be important for designing new vaccines to prevent this global public health problem. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|