Reduced Forced Vital Capacity in an African Population. Prevalence and Risk Factors
Autor: | Daniel O. Obaseki, Peter Burney, Gregory E. Erhabor, O.F. Awopeju, Emerita A. Sonia Buist, Bamidele O. Adeniyi, Olufemi O. Adewole |
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Přispěvatelé: | Wellcome Trust |
Rok vydání: | 2017 |
Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Vital capacity National Health and Nutrition Examination Survey Vital Capacity spirometry Black People Nigeria Overweight White People Pulmonary Disease Chronic Obstructive 03 medical and health sciences FEV1/FVC ratio Sex Factors 0302 clinical medicine Reference Values Risk Factors Prevalence Humans Medicine 030212 general & internal medicine Lung Aged Original Research medicine.diagnostic_test business.industry Age Factors lung function Middle Aged respiratory system Nutrition Surveys medicine.disease FVC Obstructive lung disease respiratory tract diseases 030228 respiratory system Multivariate Analysis Linear Models Physical therapy Female medicine.symptom Underweight business Body mass index circulatory and respiratory physiology Demography |
Zdroj: | Annals of the American Thoracic Society. 14:714-721 |
ISSN: | 2325-6621 2329-6933 |
Popis: | Rationale: Black Africans have reduced FVC compared with white persons, but the prevalence and determinants of reduced values are not well understood. Objectives: To evaluate the prevalence and factors leading to reduced FVC in a Nigerian population and to examine current theories regarding the determinants of this difference. Methods: We studied the ventilatory function of 883 adults aged 40 years or older participating in the Burden of Obstructive Lung DiseaseStudyinIle-Ife,Nigeria.Respondentscompletedpre-andpost- bronchodilator spirometry test and provided information on their smoking history, respiratory symptoms, risk factors, and diagnoses, including anthropometric details. We used standard categories to de fi ne body mass index as either underweight, normal, overweight, or obese. We de fi ned reduced FVC as a post-bronchodilator FVC below the lower limit of normal using National Health and Nutrition Examination Survey (NHANES) equations, Global Lung Function Initiative 2012 equations, and local reference equations based on nonsmoking study participants without a respiratory diagnosis. We fi t multivariate linear regression models to FVC as a continuous measure, adjusting for age, sex, height, and other confounders. Results: The prevalence of reduced FVC was 70.4% for men and 72.8% for women when using NHANES values for white Americans, 17.8% for men and 14.4% for women using NHANES equations for African Americans, and 15.5% for men and 20.5% for women using the Global Lung Function Initiative 2012 equations. Using the equations derived from nonsmoking respondents in the survey without a respiratory diagnosis, the prevalence of reduced FVC was less than 4% for both men and women. FVC was lower in participants who had less than 7 years of education (FVC, 2 96 ml; 95% con fi dence interval [CI], 2 172 to 2 19), were underweight (FVC, 2 269 ml; 95% CI, 2 464 to 2 73), were overweight (FVC, 2 132 ml; 95% CI, 2 219 to 2 46), and were obese (FVC, 2 222 ml; 95% CI, 2 332 to 2 112). Conclusions: There is a wide variation in the prevalence of reduced FVC based on the reference standard used. This variation is not satisfactorily explained by factors thought to affect FVC within individual populations. However, the prevalence strongly associates with both education level and body mass index in this population, regardless of the speci fi c standard used. |
Databáze: | OpenAIRE |
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