Reduced Forced Vital Capacity in an African Population. Prevalence and Risk Factors

Autor: Daniel O. Obaseki, Peter Burney, Gregory E. Erhabor, O.F. Awopeju, Emerita A. Sonia Buist, Bamidele O. Adeniyi, Olufemi O. Adewole
Přispěvatelé: Wellcome Trust
Rok vydání: 2017
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_specialty
Vital capacity
National Health and Nutrition Examination Survey
Vital Capacity
spirometry
Black People
Nigeria
Overweight
White People
Pulmonary Disease
Chronic Obstructive
03 medical and health sciences
FEV1/FVC ratio
Sex Factors
0302 clinical medicine
Reference Values
Risk Factors
Prevalence
Humans
Medicine
030212 general & internal medicine
Lung
Aged
Original Research
medicine.diagnostic_test
business.industry
Age Factors
lung function
Middle Aged
respiratory system
Nutrition Surveys
medicine.disease
FVC
Obstructive lung disease
respiratory tract diseases
030228 respiratory system
Multivariate Analysis
Linear Models
Physical therapy
Female
medicine.symptom
Underweight
business
Body mass index
circulatory and respiratory physiology
Demography
Zdroj: Annals of the American Thoracic Society. 14:714-721
ISSN: 2325-6621
2329-6933
Popis: Rationale: Black Africans have reduced FVC compared with white persons, but the prevalence and determinants of reduced values are not well understood. Objectives: To evaluate the prevalence and factors leading to reduced FVC in a Nigerian population and to examine current theories regarding the determinants of this difference. Methods: We studied the ventilatory function of 883 adults aged 40 years or older participating in the Burden of Obstructive Lung DiseaseStudyinIle-Ife,Nigeria.Respondentscompletedpre-andpost- bronchodilator spirometry test and provided information on their smoking history, respiratory symptoms, risk factors, and diagnoses, including anthropometric details. We used standard categories to de fi ne body mass index as either underweight, normal, overweight, or obese. We de fi ned reduced FVC as a post-bronchodilator FVC below the lower limit of normal using National Health and Nutrition Examination Survey (NHANES) equations, Global Lung Function Initiative 2012 equations, and local reference equations based on nonsmoking study participants without a respiratory diagnosis. We fi t multivariate linear regression models to FVC as a continuous measure, adjusting for age, sex, height, and other confounders. Results: The prevalence of reduced FVC was 70.4% for men and 72.8% for women when using NHANES values for white Americans, 17.8% for men and 14.4% for women using NHANES equations for African Americans, and 15.5% for men and 20.5% for women using the Global Lung Function Initiative 2012 equations. Using the equations derived from nonsmoking respondents in the survey without a respiratory diagnosis, the prevalence of reduced FVC was less than 4% for both men and women. FVC was lower in participants who had less than 7 years of education (FVC, 2 96 ml; 95% con fi dence interval [CI], 2 172 to 2 19), were underweight (FVC, 2 269 ml; 95% CI, 2 464 to 2 73), were overweight (FVC, 2 132 ml; 95% CI, 2 219 to 2 46), and were obese (FVC, 2 222 ml; 95% CI, 2 332 to 2 112). Conclusions: There is a wide variation in the prevalence of reduced FVC based on the reference standard used. This variation is not satisfactorily explained by factors thought to affect FVC within individual populations. However, the prevalence strongly associates with both education level and body mass index in this population, regardless of the speci fi c standard used.
Databáze: OpenAIRE
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