Statistical geometry of pancreatic islets
Autor: | K. Gorray, Guy Maytal, Micheline A. Schreiber, J. Maimon, Harold M. Hastings, Bruce S. Schneider |
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Rok vydání: | 1992 |
Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Guinea Pigs Biology Models Biological General Biochemistry Genetics and Molecular Biology Statistical geometry Diabetes Mellitus Experimental Islets of Langerhans Animal model Internal medicine Alloxan medicine Animals General Environmental Science geography geography.geographical_feature_category General Immunology and Microbiology Regeneration (biology) Pancreatic islets General Medicine Islet Glandula endocrina Endocrinology medicine.anatomical_structure General Agricultural and Biological Sciences Neuroscience Mathematics |
Zdroj: | Proceedings. Biological sciences. 250(1329) |
ISSN: | 0962-8452 |
Popis: | Quantitative histomorphometric studies of the dynamics of growth and development of pancreatic islets in normal and pathological states pose substantial methodological and conceptual problems. We address these problems with the geometry of random fractals, and apply our methods to the analysis of islet regeneration in the alloxan-treated guinea-pig. In both experimental islet-regenerated and control animals, islet centres are found to cluster in similar fractal subsets of dimension strictly less than 3, in agreement with the postulated origin of islets along a system of ductules, and suggesting that regeneration follows the same mathematical dynamics as original islet formation. |
Databáze: | OpenAIRE |
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