Renewing an old interest: Pituitary folliculostellate cells

Autor: Patrice Mollard, Paul Le Tissier
Přispěvatelé: University of Edinburgh, Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Guerineau, Nathalie C.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Cell type
Pituitary gland
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Population
030209 endocrinology & metabolism
pulse generation
[SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
Biology
folliculostellate cells
03 medical and health sciences
Cellular and Molecular Neuroscience
Paracrine signalling
0302 clinical medicine
Endocrinology
SOX2
Anterior pituitary
Pituitary Gland
Anterior
Pituitary Hormones
Anterior
Internal medicine
cell networks
[SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]
medicine
education
Cells
Cultured
030304 developmental biology
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
0303 health sciences
education.field_of_study
Endocrine and Autonomic Systems
[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Gap Junctions
Stem-cell therapy
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Cell biology
medicine.anatomical_structure
Pituitary Gland
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Endocrine Cells
Stem cell
anterior pituitary
Zdroj: Journal of Neuroendocrinology
Journal of Neuroendocrinology, Wiley, 2021, pp.e13053. ⟨10.1111/jne.13053⟩
Journal of Neuroendocrinology, 2021, 33 (11), pp.e13053. ⟨10.1111/jne.13053⟩
ISSN: 0953-8194
1365-2826
Popis: International audience; Anterior pituitary folliculostellate (FS) cells, first described almost 50 years ago, have a wide range of functions with respect to supporting and coordinating endocrine cell function, in particular through paracrine and gap junction-mediated signalling. Our previous studies identified the morphological organisation of FS cells, which mediates coordinated calcium activity throughout the homotypic FS network and allows signalling across the whole pituitary gland. It is also clear that FS cells can modify endocrine output and feedback on pituitary axes over a range of timescales. Recently, several studies have defined FS cells as a source of anterior pituitary endocrine cell renewal, which has resulted in a renaming of FS cells as "Sox2+ve stem cells". Here, we highlight the broader potential of the FS cell population in fine-tuning and coordinating pituitary axes function. In addition, we identify a need for: the definition of the possible subtypes of FS cell and their relationship with the stem cell population; the potential role of FS cells in pulsatile hormone secretion and coordination of heterotypic cell networks; and the roles that FS cells may play in both early-life programming of pituitary axes and in memory, or anticipation, of demand. Further studies of FS cells may demonstrate the fundamental importance of this cell type and its potential as a therapeutic target to correct pituitary gland dysfunction, one of which is stem cell therapy. Clearly, a thorough understanding of all of these interactions and relationships of FS and endocrine cells is required whatever therapeutic use is suggested by their various roles.
Databáze: OpenAIRE
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