| Autor: |
Osamu Noritake, Keiju Aokage, Ayako Suzuki, Kenta Tane, Tomohiro Miyoshi, Joji Samejima, Toyohumi Yoshikawa, Shawhay Charles Murata, Tokiko Nakai, Masahiro Tsuboi, Genichiro Ishii |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of cancer research and clinical oncology. 148(12) |
| ISSN: |
1432-1335 |
| Popis: |
Intratumoral macrophages are reportedly involved in tumor progression in non-small cell lung cancer; however, little is known about the prognostic impact and function of alveolar macrophages (AMs). This study aims to investigate the prognostic impact of the number of peri-tumoral AMs in patients with stage I lung adenocarcinoma.We investigated 514 patients with pathological stage I lung adenocarcinoma who underwent complete resection with lobectomy or pneumonectomy. The numbers of peri-tumoral AMs were counted, and patients were classified into two groups based on the number of peri-tumoral AMs. Using the Cancer Genome Atlas (TCGA) database of stage I lung adenocarcinoma, we compared gene expression profiles of high and low peri-tumoral AM contents.The median number of peri-tumoral AMs per alveolar space was 15.5. Patients with a high peri-tumoral AM content had significantly shorter disease-free survival and overall survival than patients with a low peri-tumoral AM content (both p 0.01). In the multivariate analyses, a higher number of peri-tumoral AMs were an independent prognostic factor (p = 0.02). The analysis of TCGA database revealed that patients with a high peri-tumoral AM content had shorter disease-free survival than those with a low peri-tumoral AM content (p = 0.04). Gene expression analysis of TCGA stage I lung adenocarcinoma revealed enrichment of biological processes, such as chemotaxis and epithelial proliferation, in patients with a high peri-tumoral AM content.The number of peri-tumoral AMs had a strong impact on disease-free survival in patients with stage I lung adenocarcinoma. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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