Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis – a pilot study
| Autor: | Riitta Korpela, Tuija Poussa, Markku Korpela, Eeva Moilanen, Maija Saxelin, Heikki Vapaatalo, J Martio, Katja Hatakka, T Laasanen, M Herranen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Lactobacillus GG Adolescent Health Status medicine.medical_treatment Immunology Arthritis Pilot Projects Placebo Severity of Illness Index Gastroenterology law.invention Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Double-Blind Method Rheumatology Randomized controlled trial Lactobacillus rhamnosus law Surveys and Questionnaires Internal medicine Immunopathology medicine Humans Immunology and Allergy Aged 030304 developmental biology 030203 arthritis & rheumatology 0303 health sciences Chemotherapy biology business.industry Probiotics General Medicine Middle Aged medicine.disease biology.organism_classification 3. Good health Lactobacillus Rheumatoid arthritis Female Joints business Interleukin-1 |
| Zdroj: | Scandinavian Journal of Rheumatology. 32:211-215 |
| ISSN: | 1502-7732 0300-9742 |
| Popis: | To study the effects of Lactobacillus rhamnosus GG (LGG) on rheumatoid arthritis (RA).Twenty-one RA patients were randomised to receive 2 capsules of LGG or a placebo twice daily in double-blind fashion for 12 months. Arthritis activity was evaluated by clinical examination, HAQ index, and laboratory tests (e.g. ESR, CRP, pro- and anti-inflammatory cytokines).There were no statistical differences in the clinical parameters, biochemical variables and HAQ index between the study groups over the intervention period. The mean number of tender and swollen joints decreased from 8.3 to 4.6 in the Lactobacillus group and from 5.5 to 4.8 in the placebo group (p = 0.41). According to the global assessment the RA activity was reduced in 71% (LGG group) vs. 30% (controls) (p = 0.15). Serum IL-1 beta increased slightly in the LGG group (p = 0.07), but no differences were seen in IL-6, TNF-alpha, MPO, IL-10 or 1L-12.Although there were no statistical significant differences in the activity of RA, more subjects in the LGG group reported subjective well being. More studies on the effects of probiotic bacteria in RA are needed. |
| Databáze: | OpenAIRE |
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