Towards a new WHO classification of renal cell tumor: what the clinician needs to know—a narrative review
| Autor: | Veronica Mollica, Marina Scarpelli, Alessia Cimadamore, Francesco Massari, Matteo Santoni, Antonio Lopez-Beltran, Rodolfo Montironi, Holger Moch, Liang Cheng |
|---|---|
| Přispěvatelé: | University of Zurich, Cimadamore, Alessia, Cimadamore A., Cheng L., Scarpelli M., Massari F., Mollica V., Santoni M., Lopez-Beltran A., Montironi R., Moch H. |
| Rok vydání: | 2021 |
| Předmět: |
2748 Urology
0301 basic medicine Oncology medicine.medical_specialty Urology 610 Medicine & health Anaplastic lymphoma kinase (ALK) Classification Clear cell RCC Emerging entities Fumarate hydratase (FH) Molecular pathology Non-clear cells RCC Renal cell carcinoma Succinate dehydrogenase (SDH) Von hippel-lindau gene (VHL) urologic and male genital diseases Renal neoplasm Renal medullary carcinoma 03 medical and health sciences Collecting duct carcinoma 0302 clinical medicine 10049 Institute of Pathology and Molecular Pathology Internal medicine Medicine Pathological business.industry Emerging entitie Cancer 2743 Reproductive Medicine medicine.disease female genital diseases and pregnancy complications 030104 developmental biology Reproductive Medicine 030220 oncology & carcinogenesis Review Article on Update on Molecular Classification and Individualized Treatments of Genitourinary Tumors business Who classification |
| Zdroj: | Transl Androl Urol |
| ISSN: | 2223-4691 2223-4683 |
| DOI: | 10.21037/tau-20-1150 |
| Popis: | In 1952, renal cell carcinomas had been divided into 2 categories-clear cell or granular cell-depending upon their cytoplasmic staining characteristics. In the following years, the inventory of renal epithelial tumors has expanded by the addition of tumors named by their architectural pattern (i.e., papillary RCC, tubulocystic RCC), anatomic location (i.e., collecting duct carcinoma, renal medullary carcinoma), associated diseases (i.e., acquired cystic disease-associated RCCs). With the extensive application of molecular diagnostic techniques, it becomes possible to detect genetic distinctions between various types of renal neoplasm and discover new entities, otherwise misdiagnosed or diagnosed as unclassified RCC. Some tumors such as ALK rearrangement-associated RCC, MiT family translocation renal carcinomas, SDH-deficient renal cancer or FH-deficient RCC, are defined by their molecular characteristics. The most recent World Health Organization (WHO) classification of renal neoplasms account for more than 50 entities and provisional entities. New entities might be included in the upcoming WHO classification. The aim of this review is to summarise and discuss the newly acquired data and evidence on the clinical, pathological, molecular features and on the prognosis of new RCC entities, which will hopefully increase the awareness and the acceptance of these entities among clinicians and improve prognostication for individual patients. |
| Databáze: | OpenAIRE |
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