Impact of rituximab on relapse rate and disability in neuromyelitis optica
| Autor: | Andrew D Brown, Byron L. Lam, Sylvia Delgado, William A. Sheremata, Gurdesh Bedi, Nida Usmani |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Antibodies Monoclonal Murine-Derived Disability Evaluation 03 medical and health sciences 0302 clinical medicine Internal medicine Secondary Prevention medicine Demyelinating disease Humans Immunologic Factors Longitudinal Studies 030212 general & internal medicine Retrospective Studies CD20 Neuromyelitis optica biology business.industry Multiple sclerosis Neuromyelitis Optica Retrospective cohort study medicine.disease Treatment Outcome Neurology Monoclonal Immunology biology.protein Female Rituximab Neurology (clinical) Antibody business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Multiple Sclerosis Journal. 17:1225-1230 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1177/1352458511404586 |
| Popis: | Background: Neuromyelitis optica (NMO) is a severe demyelinating disease often leading to serious disability. Accumulating evidence now implicates humoral mechanisms in its pathogenesis. In the absence of an approved therapy, anti-inflammatory/immunosuppressant drugs have been used empirically for more than three decades. Recent evidence for a role of antibody to aquaporin-4 in the pathogenesis of NMO has led to the use of rituximab, a monoclonal antibody targeting the CD20 epitope on the entire B cell lineage. Objectives: To evaluate the impact of rituximab on the relapse rate and disability in NMO. Methods: This is an IRB approved retrospective longitudinal study of NMO patients treated with rituximab. Results: We identified 53 patients with NMO, 23 of whom had been treated with rituximab. These patients (2 males, 21 females) had a mean age of 37.1 ± 14.6 years at the time of diagnosis. Eight of the 23 treated with rituximab were treatment naïve. All 23 were scheduled to receive infusions every six or 12 months after treatment initiation with a minimum follow-up of six months (median 32.5 months, range 7–63 months). Median relapse rate declined significantly from 1.87 relapses/patient per year to 0.0 relapses/patient per year. Kurtzke Expanded Disability Status Scale (EDSS) scores stabilized or improved in all patients. Use of rituximab is associated with a significant reduction in relapses and disability in patents with NMO. |
| Databáze: | OpenAIRE |
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