Synthesis of some thiazolyl aminobenzothiazole derivatives as potential antibacterial, antifungal and anthelmintic agents
| Autor: | Nikhil D. Amnerkar, Kishore P. Bhusari |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Antifungal
Antifungal Agents Magnetic Resonance Spectroscopy Gram-negative bacteria Stereochemistry medicine.drug_class Gram-positive bacteria Microbial Sensitivity Tests Gram-Positive Bacteria Mass Spectrometry Structure-Activity Relationship chemistry.chemical_compound Acetamides Gram-Negative Bacteria Drug Discovery medicine Animals Anthelmintic Oligochaeta Thiazole Anthelmintics Pharmacology Molecular Structure biology Fungi General Medicine Antimicrobial biology.organism_classification Corpus albicans Anti-Bacterial Agents Thiazoles chemistry Antibacterial activity medicine.drug |
| Zdroj: | Journal of Enzyme Inhibition and Medicinal Chemistry. 26:22-28 |
| ISSN: | 1475-6374 1475-6366 |
| DOI: | 10.3109/14756360903555258 |
| Popis: | A series of 4-(6-substituted-1,3-benzothiazol-2-yl)amino-2-(4-substitutedphenyl)- amino-1,3-thiazoles, 9-24 have been synthesised from 2-chloro-N-(6-substituted-1,3-benzothiazol-2-yl)acetamides, 5-8. The structures of these compounds have been elucidated by spectral (IR, (1)H NMR, Mass) and elemental (C, H, N) analysis data. All the newly synthesised compounds (9-24) were screened for their antibacterial, antifungal and anthelmintic activities. Almost all of these compounds showed moderate to good antimicrobial activity against two gram negative bacteria (E. coli, P. aeruginosa), two gram positive bacteria (S. aureus, B. subtilis), pathogenic fungal strains (C. albicans, A. niger) and good anthelmintic activity against earthworm species (P. corethruses). Compounds 18 and 20 exhibited good antibacterial and antifungal activities, while compound 22 displayed the most significant anthelmintic activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |