Hepatic artery hemodynamic responsiveness to altered portal blood flow in normal and cirrhotic livers
| Autor: | Chizuru Tayama, Tadashi Iwao, Hideo Masumoto, Teruhiro Sakai, Masahiro Sato, Kazuhiko Oho, Hiroyuki Shigemori, Atsushi Toyonaga, Kyuichi Tanikawa |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Vasopressin Cirrhosis Time Factors Haemodynamic response Vasopressins Hemodynamics Hepatic Artery Reference Values Internal medicine medicine Humans Vasoconstrictor Agents Radiology Nuclear Medicine and imaging Prospective Studies Observer Variation Ultrasonography Doppler Duplex business.industry Blood flow Fasting Middle Aged medicine.disease Surgery medicine.anatomical_structure Circulatory system Vascular resistance Cardiology Female business Artery Liver Circulation |
| Zdroj: | Radiology. 200(3) |
| ISSN: | 0033-8419 |
| Popis: | To compare hepatic artery hemodynamic response to altered portal blood flow in normal and cirrhotic livers.The portal blood flow and hepatic artery pulsatility index were measured by means of duplex ultrasound before and after subjects (eight control subjects and 10 cirrhotic patients) ingested a 500-kcal mixed-liquid meal and during intravenous infusion of vasopressin at a rate of 0.3 U/min (nine control and nine cirrhotic subjects). The hepatic artery buffer index (ratio of maximum change from baseline in hepatic artery pulsatility index to maximum change from baseline in portal blood flow) was also calculated.Meal consumption increased the portal blood flow and hepatic artery pulsatility index in all subjects. The hepatic artery buffer index, however, was significantly lower in cirrhotic than in control subjects (0.67 min/L +/- 0.06 [standard error of the mean] vs 1.54 min/L +/- 0.20, respectively; P.01). Vasopressin infusion decreased the portal blood flow and hepatic artery pulsatility index in all subjects. Again, the hepatic artery buffer index was significantly lower in cirrhotic than in control subjects (0.28 min/L +/- 0.07 vs 0.50 min/L +/- 0.04, respectively; P.05).Hepatic artery vascular responsiveness to altered portal blood flow is blunted in cirrhotic livers. |
| Databáze: | OpenAIRE |
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