Transgenerational transmission of small‐for‐gestational age

Autor: Álvaro Sepúlveda-Martínez, Francesca Crovetto, Merida Rodriguez-Lopez, E. Gratacós, Fatima Crispi, G. Casu, F. Paz y Miño
Přispěvatelé: Universitat de Barcelona
Rok vydání: 2019
Předmět:
Adult
Male
Gestational hypertension
medicine.medical_specialty
pre-eclampsia
Placenta Diseases
Offspring
Gestational Age
Fetal growth
Cohort Studies
Young Adult
Pregnancy
Interquartile range
Prenatal medicine
Prevalence
medicine
Humans
transgenerational
Genetic Predisposition to Disease
Radiology
Nuclear Medicine and imaging
small-for-gestational age
reproductive and urinary physiology
Creixement fetal
Radiological and Ultrasound Technology
Placental abruption
Obstetrics
business.industry
Medicina prenatal
transmission
Infant
Newborn
Obstetrics and Gynecology
General Medicine
Infant
Low Birth Weight
medicine.disease
Placental disease
female genital diseases and pregnancy complications
Reproductive Medicine
Spain
Infant
Small for Gestational Age
Regression Analysis
Small for gestational age
placental disease
Female
business
Cohort study
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
ISSN: 1469-0705
0960-7692
DOI: 10.1002/uog.20119
Popis: OBJECTIVE: To evaluate the transgenerational transmission of small-for-gestational age (SGA). METHODS: This was a cohort study of a random sample of 2043 offspring delivered between 1975 and 1993 at Hospital Sant Joan de Déu in Barcelona. Exclusion criteria were multiple pregnancy, aneuploidy or genetic syndrome, major birth defects, severe mental disease and macrosomia. Eligible individuals were contacted and those with at least one offspring were included in the study. Participants were classified according to the presence of SGA (defined as birth weight < 10(th) percentile) at birth. Multiple regression analysis was used to determine the presence of SGA or placenta-mediated disease (defined as the presence of SGA, pre-eclampsia, gestational hypertension and/or placental abruption) in the following generation. RESULTS: Of 623 individuals who agreed to participate, 152 (72 born SGA and 80 born appropriate-for-gestational age (AGA)) were reported to have at least one child. Descendants of SGA individuals presented with a lower birth-weight percentile (median, 26 (interquartile range (IQR), 7-52) vs 43 (IQR, 19-75); P < 0.001) and a higher prevalence of SGA (40.3% vs 16.3%; P = 0.001) and placenta-mediated disease (43.1% vs 17.5%; P = 0.001) than did the offspring of AGA individuals. After adjustment for confounding variables, parental SGA background was associated with an almost three-fold increased risk of subsequent SGA or any placenta-mediated disease in the following generation. This association was stronger in SGA mothers than in SGA fathers. CONCLUSIONS: Our data provide evidence suggesting a transgenerational transmission of SGA, highlighting the importance of public health strategies for preventing intrauterine growth impairment. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
Databáze: OpenAIRE
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