The role of the calcitonin receptor in protecting against induced hypercalcemia is mediated via its actions in osteoclasts to inhibit bone resorption
| Autor: | Jarrod P Skinner, Rebecca Sawyer, A.J. Moore, Howard A. Morris, Francisca Tjahyono, Jeffrey D Zajac, David M. Findlay, Andrew G. Turner, Rachel A Davey, W.S. Maria Chiu |
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| Přispěvatelé: | Turner, Andrew G, Tjahyono, Francisca, Chiu, W.S Maria, Skinner, Jarrod, Sawyer, Rebecca, Moore, Alison J, Morris, Howard A, Findlay, David M, Zajac, Jeffrey D, Davey, Rachel A |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Histology Genotype Bone disease Calcitriol Physiology Endocrinology Diabetes and Metabolism Osteoclasts chemistry.chemical_element knockout Mice Transgenic Calcium Polymerase Chain Reaction bone Bone resorption Mice Osteoclast Internal medicine medicine calcitonin receptor Animals Bone Resorption Calcitonin receptor Receptor Mice Knockout Chemistry hypercalcemia Receptors Calcitonin medicine.disease Endocrinology medicine.anatomical_structure Calcitonin Hypercalcemia Female medicine.drug |
| Popis: | Despite the therapeutic value of calcitonin in treating bone disease, a biological role of endogenous calcitonin is controversial. Having previously demonstrated that the CTR has a biological role in protecting against calcium stress using a global CTRKO mouse model, the purpose of this study was to determine whether the protection conferred by the CTR during induced hypercalcemia is mediated via CTR expression on osteoclasts. Mice were generated, in which the CTR was deleted specifically within osteoclasts (OCL-CTRKOs) and compared with mice in which the CTR was deleted globally (global CTRKOs). Significantly, peak serum calcium levels following induced hypercalcemia were N18% higher in global-CTRKOs and OCL-CTRKOs than controls (Pb0.01) due to increased bone resorption (Pb0.05). Peak serum calcium levels relative to controls were greater in global-CTRKO males than OCL-CTRKO males (Pb0.001), which may, at least in part, be due to increased reabsorption of calcium in the kidney (Pb0.01). Controls for all analyses were sex-matched littermates with normal CTR expression. In conclusion, the CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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