Potential predictors for prognosis and postpartum recovery time of acute fatty liver of pregnancy

Autor:	Cheng-Jin Liao, Min Qi, Xingwang Hu, Li-Yuan Long, Ze-Bing Huang, Jun Chen, Xue-Gong Fan, Yan Huang
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Adult medicine.medical_specialty Time Factors Potential predictors Blood Component Transfusion Acute fatty liver of pregnancy Logistic regression Risk Assessment lcsh:Gynecology and obstetrics Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Statistical significance Internal medicine medicine Humans Hepatic encephalopathy Postpartum Recovery lcsh:RG1-991 Retrospective Studies Univariate analysis Factor VIII 030219 obstetrics & reproductive medicine business.industry Mortality rate Postpartum Period Fibrinogen Obstetrics and Gynecology medicine.disease Prognosis Liver Artificial Fatty Liver Pregnancy Complications Hepatic Encephalopathy Cryoprecipitate Postpartum recovery time Female 030211 gastroenterology & hepatology business Research Article
Zdroj:	BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-8 (2020) BMC Pregnancy and Childbirth
ISSN:	1471-2393
DOI:	10.1186/s12884-020-03287-y
Popis:	Background Acute fatty liver of pregnancy (AFLP) is a potentially lethal condition of pregnant women with a high mortality rate. Potential predictors related to postpartum recovery time and prognostic factors of AFLP are still unclear. This study aimed to evaluate potential predictors for prognosis and postpartum recovery time of AFLP. Methods We retrospectively analyzed the clinical data of 76 AFLP patients in our hospital from 2002 to 2017 and investigated potential predictors using univariate analysis and multivariate logistic regression analysis. Results Hepatic encephalopathy (HE) was found to be associated with prognosis in AFLP patients (P = 0.005, OR = 26.844). The postpartum recovery time analysis showed that AFLP patients with a age P = 0.134, OR = 5.952). The postpartum recovery time of patients with liver failure (LF) was significantly prolonged compared to those without LF (P = 0.036, OR = 10.052). Cryoprecipitate, and plasma infusion showed no significant effect on prognosis or recovery time. Artificial liver support therapy (ALST) had no effect on prognosis, but it might affect postpartum recovery time with no statistical significance (P = 0.128, OR = 5.470). Conclusion HE is a potential predictor for prognosis of AFLP. LF is a potential predictor for postpartum recovery time.
Databáze:	OpenAIRE
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