miR-203 Suppresses the Proliferation and Metastasis of Hepatocellular Carcinoma by Targeting Oncogene ADAM9 and Oncogenic Long Non-coding RNA HULC
| Autor: | Jian Wu, Sutong Wang, Liya A, Shunli Shen, Qiaoming Zhi, Dingcheng Zheng, Coder Brandon, Shun-Jun Fu, Yixing Guo, Chenglong Shen, Wenxuan Xie, Daiwei Wan, Songbing He, Baogang Peng, Burnley Preston, Bin R. Chen |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cancer Research Carcinoma Hepatocellular HULC Down-Regulation Apoptosis Biology Metastasis 03 medical and health sciences 0302 clinical medicine Cell Line Tumor microRNA medicine Humans Neoplasm Metastasis Cell Proliferation Pharmacology Oncogene Liver Neoplasms Membrane Proteins Middle Aged medicine.disease Long non-coding RNA ADAM Proteins MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell Cancer research Molecular Medicine Female RNA Long Noncoding ADAM9 miR-203 |
| Zdroj: | Anti-Cancer Agents in Medicinal Chemistry. 16:414-423 |
| ISSN: | 1871-5206 |
| Popis: | MicroRNAs (miRNAs) have been integrated into tumorigenic programs by regulating genes at post-transcriptional level. Long non-coding RNAs (lncRNAs) are novel targets for miRNAs. Here, we reported that miR-203 down-regulation was closely linked to advanced clinical features and poor overall survival (OS) of patients with hepatocellular carcinoma. We also confirmed that miR-203 and oncogene ADAM9 (a disintegrin and metalloproteinase 9)/oncogenic long non-coding RNA HULC (highly up-regulated in liver cancer) were inversely expressed in hepatocellular carcinoma (HCC) tissues or cell lines. More intriguingly, up-regulation of miR-203 diminished the expression of ADAM9 and HULC in HCC cancer cells. Over-expression of miR-203 could markedly inhibit cell proliferation, invasion and induce cell apoptosis. Furthermore, we identified that miR-203 modulated ADAM9 and HULC in a novel post-transcriptional regulatory mechanism. Over-expression of HULC partly rescued the miR-203-mediated antitumor effects. These results suggested that miR-203 played tumor suppressive roles by downregulating ADAM9 and HULC and indicated its potential application in cancer treatment. |
| Databáze: | OpenAIRE |
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