Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial
Autor: | Xue-feng Zeng, Yun-xia Zuo, Ru-rong Wang, Yan Kang, Gong Cheng, Xiao-jin Li, Jin Liu |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
Surviving Sepsis Campaign Article Subject Septic shock business.industry 030208 emergency & critical care medicine lcsh:Other systems of medicine medicine.disease lcsh:RZ201-999 Gastroenterology Surgery Log-rank test Clinical trial 03 medical and health sciences 0302 clinical medicine Complementary and alternative medicine Internal medicine Heart rate medicine 030212 general & internal medicine Safflower yellow business Survival analysis Severe sepsis Research Article |
Zdroj: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2016 (2016) |
ISSN: | 1741-4288 1741-427X |
Popis: | Objective.To evaluate the clinical effect of safflower yellow on the treatment of severe sepsis and septic shock.Methods.85 patients with severe sepsis and septic shock were randomly selected to receive either therapy according to the international guidelines for management of severe sepsis and septic shock (Surviving Sepsis Campaign 2012) (control group,n= 45) or conventional therapy plus safflower yellow (study group,n= 40). The 28-day mortality and 28-day Kaplan-Meier survival curves were compared as primary outcomes.Results.The 28-day mortality from all causes and in-hospital mortality were significantly lower in the study group (50%, 17.5%) as compared to the control group (78.58%, 54.76%) (P= 0.007, all causes,P< 0.001, in-hospital), and the 28-day Kaplan-Meier survival curve was higher in the study group than in the control group (P= 0.008, all causes,P< 0.001, in-hospital, Log Rank). 72 hours after treatment, secondary outcomes including heart rate, leukocyte counts, lactate levels, and platelet counts of patients in the study group were ameliorated significantly as compared with the control group.Conclusion.This study offers a potential new strategy employing safflower yellow to more effectively treat patients with severe sepsis and septic shock. This trial is registered with identifierChiCTR-TRC-14005196. |
Databáze: | OpenAIRE |
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