A concise synthesis of a novel antiangiogenic tyrosine kinase inhibitor
| Autor: | Michael H. Kress, Louis Matty, James M. McNamara, Joseph F. Payack, Enrique Vazquez |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Indole test Indoles biology Bicyclic molecule Molecular Structure medicine.drug_class Stereochemistry Organic Chemistry Angiogenesis Inhibitors Protein-Tyrosine Kinases Tyrosine-kinase inhibitor Catalysis Piperazines chemistry.chemical_compound Enzyme Suzuki reaction chemistry Enzyme inhibitor medicine biology.protein Organic synthesis Indicators and Reagents |
| Zdroj: | The Journal of organic chemistry. 70(1) |
| ISSN: | 0022-3263 |
| Popis: | An efficient synthesis of the potent KDR inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indole-2-yl]quinolin-2(1H)-one (1) is described. The process features a noncryogenic indole boronation and a dicyclohexylamine-mediated Suzuki coupling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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