Molecular cloning of the cDNA encoding A+U-rich element RNA binding factor
| Autor: | Takahiko Shiosaka, Shigeru Fujita, Yoko Takaoka, Ayako Doi, Kohsuke Yanagisawa |
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| Rok vydání: | 1998 |
| Předmět: |
DNA
Complementary Molecular Sequence Data Biophysics Molecular cloning Polymerase Chain Reaction Biochemistry Leukemia Myelomonocytic Acute Homology (biology) Protein sequencing Rapid amplification of cDNA ends Structural Biology Complementary DNA Eosinophilia Tumor Cells Cultured Genetics Humans Heterogeneous Nuclear Ribonucleoprotein D0 Amino Acid Sequence Cloning Molecular Heterogeneous-Nuclear Ribonucleoprotein D Messenger RNA Base Sequence Sequence Homology Amino Acid Chemistry RNA-Binding Proteins RNA Sequence motif |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1396:51-56 |
| ISSN: | 0167-4781 |
| DOI: | 10.1016/s0167-4781(97)00223-6 |
| Popis: | Using the differential display method, a new cDNA clone, termed laAUF1, encoding the human A+U-rich RNA-binding motif was isolated and sequenced. Analysis of the protein sequence of laAUF1 indicates 73% homology between the deduced polypeptide sequences of laAUF1 and AUF1 in the region encoding a consensus motif for two non-identical RNA recognition motifs (RRMs) and Gln-rich motif. We suggest that the similar affinities of laAUF1 and AUF1 for particular A+U-rich elements (ARE) sequences are related to their potencies as mRNA destabilizers. |
| Databáze: | OpenAIRE |
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