Additional file 2: of Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2–IL-6 cascade

Autor: Chen, Yong-Qiang, Li, Peng-Cheng, Pan, Ning, Gao, Rong, Zhi-Fa Wen, Zhang, Tian-Yu, Huang, Fang, Fang-Yuan Wu, Ou, Xi-Long, Zhang, Jin-Ping, Zhu, Xue-Jun, Hu, Hong-Ming, Chen, Kang, Yun-Lang Cai, Wang, Li-Xin
Rok vydání: 2019
DOI: 10.6084/m9.figshare.8867129.v1
Popis: Figure S1. Effect of TRAPs on differentiation of CD4+ T cells. Figure S2. Comparison of LC3B+ EVs and LC3B− EVs in instructing CD4+ T cells. Figure S3 TRAPs induce Akt/p38/NF-κB/STAT3 activation in CD4+ T cells via the TLR2–MyD88 pathway. Figure S4 IL-10 and IL-21 production by TRAPs-induced CD4+ T cells occurs via autocrine IL-6. Figure S5 Hsp90α on TRAPs is essential for the induction of IL-6 secretion from CD4+ T cells. Figure S6. The secretion of cytokines from TRAPs-induced CD4+ T cells (TTRAP) mediate IL-10-producing B cell differentiation. Figure S7 Evaluation of Beclin-1 expression in B16F10 cells. Figure S8 Depletion of selected cellular subsets during tumor growth. (DOCX 2.11 mb)
Databáze: OpenAIRE