Full-field sensitivity threshold and the relation to the oxygen metabolic retinal function in retinitis pigmentosa

Autor: Olga Zabek, Giacomo Calzetti, Dominique Prétot, Hendrik P. N. Scholl, Maria della Volpe Waizel
Rok vydání: 2022
Předmět:
Zdroj: Graefe's Archive for Clinical and Experimental Ophthalmology. 260:2517-2527
ISSN: 1435-702X
0721-832X
DOI: 10.1007/s00417-022-05638-1
Popis: The aim of our study was to evaluate retinal function with white light dark-adapted full-field sensitivity threshold (FST) and find possible correlations with metabolic function measured with retinal oximetry (RO) in patients with retinitis pigmentosa (RP).In this prospective observational study (BASEC 2020-00,122), FST and RO measurements were performed on 66 RP eyes (33 subjects, 12♀ 21♂) aged between 18 and 80 years (mean 43.2 years); all eyes were graded for disease severity. Main outcome parameters were white FST thresholds using the Diagnosys Espion system with the ColorDomeTM LED full-field stimulator (Diagnosys LLC, Lowell, MA) as well as the main RO parameters: the mean arterial (A-SONeither the oxygen saturation parameters (p 0.21) nor the D-A and D-V (p 0.13) showed significant correlations with the FST. However, when compared systematically with the visual field (VF) areas of the different isopters, RO parameters V-SOIn contrast to standardized VF parameters, white dark-adapted FST appears not to correlate with retinal oxygen metabolic function measured with RO in patients with RP, suggesting that the two examinations may capture unrelated aspects of the retinal pathological process. However, RO showed a significant association with standardized VF testing parameters and may, therefore, offer an alternative outcome measure for interventional trials.
Databáze: OpenAIRE
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