Low-dose trimetrexate glucuronate and protracted5-fluorouracil infusion in previously untreated patients with advanced pancreatic cancer
| Autor: | P. J. Rosen, Lee S. Rosen, J.R. Hecht, L.-S. Lin, R. G. Amado |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Diarrhea Male Antimetabolites Antineoplastic medicine.medical_specialty Pancreatic disease Palliative care medicine.medical_treatment Glucuronates Gastroenterology Drug Administration Schedule chemistry.chemical_compound Internal medicine Pancreatic cancer Antineoplastic Combined Chemotherapy Protocols medicine Humans Infusions Intravenous Aged Aged 80 and over Chemotherapy Dose-Response Relationship Drug business.industry Palliative Care Hematology Middle Aged medicine.disease Survival Analysis Surgery Pancreatic Neoplasms Drug Combinations Trimetrexate Oncology chemistry Tolerability Fluorouracil Antifolate Female business medicine.drug |
| Zdroj: | Annals of Oncology. 13:582-588 |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/mdf090 |
| Popis: | Background: 5-Fluorouracil (5-FU)-based regimens have not been shown to prolong survival or provide clinical benefit in patients with advanced pancreatic cancer. The purpose of this study was to determine the tolerability of protracted venous infusion (PVI) of 5-FU, modulated by a low dose of the synthetic antifolate trimetrexate, in patients with advanced pancreatic cancer. Patients and methods: Twenty-three chemotherapy-naive patients were evaluated. Patients were enrolled in four consecutive cohorts in which the weekly dose of trimetrexate was escalated in 10 mg/m 2 increments, from 20 to 50 mg/m 2 . PVI 5-FU was administered at a fixed dose of 225 mg/m 2 /day. Treatment was administered for 6 successive weeks, every 8 weeks. Results: Twenty-two patients were assessable. The maximum tolerated dose of trimetrexate was 40 mg/m 2 . The most common grade 3 and 4 toxicity was diarrhea. There were no treatment-related deaths. Preliminary analysis of activity revealed a response rate of 9%, with 41% of the patients having stable disease for a median duration of 3.8 months. The median survival for the entire group was 6.9 months (range 1–29 months). A clinical benefit response was experienced by 27.2% of patients. Conclusions: Low-dose trimetrexate can be safely administered in combination with PVI 5-FU. This treatment is well tolerated and is associated with palliative activity in advanced pancreatic cancer. |
| Databáze: | OpenAIRE |
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