Quantitative Differentiation Between Healthy and Disordered Brain Matter in Patients with Neurofibromatosis Type I Using Diffusion Tensor Imaging
| Autor: | Coriene E. Catsman-Berrevoets, Henriëtte A. Moll, A. de Goede-Bolder, S.J.P.M. van Engelen, Maarten H. Lequin, Saskia M. F. Pluijm, Ype Elgersma, Lianne C. Krab |
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| Přispěvatelé: | Radiology & Nuclear Medicine, Neurosciences, Pediatrics, Public Health, Neurology |
| Rok vydání: | 2008 |
| Předmět: |
Male
Pathology medicine.medical_specialty Neurofibromatosis 1 Adolescent Central nervous system Pediatrics Fractional anisotropy medicine Humans Radiology Nuclear Medicine and imaging In patient Child Anisotropy Observer Variation Neurofibromatosis type I business.industry Brain medicine.disease Hyperintensity Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Female Neurology (clinical) Brain matter business Diffusion MRI |
| Zdroj: | American Journal of Neuroradiology, 29, 816-822. American Society of Neuroradiology AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a0921 |
| Popis: | BACKGROUND AND PURPOSE: Hyperintensities on T2-weighted images are seen in the brains of most patients with neurofibromatosis type I (NF-1), but the origin of these unidentified bright objects (UBOs) remains obscure. In the current study, we examined the diffusion characteristics of brain tissue in children with NF-1 to test the hypothesis that a microstructural abnormality is present in NF-1. MATERIALS AND METHODS: Diffusion tensor imaging (DTI) was performed in 50 children with NF-1 and 8 controls. Circular regions of interest were manually placed in 7 standardized locations in both hemispheres, including UBO sites. Apparent diffusion coefficients (ADC), fractional anisotropy (FA), and axial anisotropy (A(m)) were used to differentiate quantitatively between healthy and disordered brain matter. Differences in eigenvalues (λ(1), λ(2), λ(3)) were determined to examine parenchymal integrity. RESULTS: We found higher ADC values for UBOs than for normal-appearing sites (P < .01) and higher ADC values for normal-appearing sites than for controls (P < .04 in 5 of 7 regions). In most regions, we found no differences in FA or A(m). Eigenvalues λ(2) and λ(3) were higher at UBO sites than in normal-appearing sites (P < .04). CONCLUSION: With ADC, it was possible to differentiate quantitatively between normal- and abnormal-appearing brain matter in NF-1 and also between normal-appearing brain matter in NF-1 and healthy brain matter in controls, indicating subtle pathologic damage disrupting the tissue microstructure in the NF-1 brain. Higher diffusivity for λ(1), λ(2), and λ(3) indicates that this disturbance of microstructure is caused by accumulation of fluid or vacuolation. |
| Databáze: | OpenAIRE |
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