Effect of 1,25-dihydroxycholecalciferol and 1,25-dihydroxycholecalciferol glycoside on 2,3-diphosphoglycerate levels of the rat erythrocyte
| Autor: | M. I. Skliar, H. Faienza, Rodolfo C. Puche, M. B. Orsatti, R. L. Boland, María del Carmen Fernández, M. E. Locatto |
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| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Calcitriol Physiology Clinical Biochemistry In vivo Physiology (medical) Internal medicine medicine Animals Diphosphoglycerate Hypoxia Pyruvates Erythropoietin chemistry.chemical_classification Red Cell Chemistry Hydroxycholecalciferols Glycoside Diphosphoglyceric Acids In vitro Sterol Rats Oxygen Endocrinology Dihydroxycholecalciferols Lactates lipids (amino acids peptides and proteins) Female medicine.drug |
| Zdroj: | Pflugers Archiv : European journal of physiology. 389(1) |
| ISSN: | 0031-6768 |
| Popis: | The erythrocytes of rats treated with 1, 25-dihydroxycholecalciferol or 1, 25-dihydroxycholecalciferol glycoside showed decreased levels of 2, 3-diphosphoglycerate. The same result has been obtained in vitro, indicating a direct effect of the sterol on the red cell. The glycoside is less active than the free sterol in vivo and more active in vitro. The decreased levels of diphosphoglycerate induced tissue hypoxia as shown by a higher plasma lactate/pyruvate ratio and a three fold increase in plasma erythropoietin concentration. |
| Databáze: | OpenAIRE |
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