Predictors of response to amine-specific antidepressants
| Autor: | D.R.L. Edwards, T. Lock, R.A. Burns, Cornelius Katona, B.L. Nairac, M.T. Abou-Saleh, D.A. Harrison, Mary M. Robertson |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Personality Inventory media_common.quotation_subject Antidepressive Agents Tricyclic Double-Blind Method Fluoxetine medicine Humans Psychiatry Lofepramine media_common Depressive Disorder Psychomotor retardation Middle Aged Sadness Psychiatry and Mental health Clinical Psychology Treatment Outcome Antidepressive Agents Second-Generation Anxiety Antidepressant Female medicine.symptom Personality Assessment Inventory Psychology Reuptake inhibitor medicine.drug Clinical psychology |
| Zdroj: | Journal of Affective Disorders. 35:97-106 |
| ISSN: | 0165-0327 |
| Popis: | Discriminant function analysis of data from a double-blind comparative trial of lofepramine (a noradrenaline-specific reuptake inhibitor) and fluoxetine (a serotonin-specific reuptake inhibitor), involving 183 patients was used to identify predictors of response. Psychic anxiety significantly predicted a positive response to antidepressant medication, whereas psychomotor retardation, observed sadness, subjective lassitude and somatic complaints were significant predictors of nonresponse. Age, gender, endogenicity, duration of illness and number of previous episodes were not predictive of response. Significant differences were found between predictors of response to fluoxetine and lofepramine (P < 0.001 all groups). Predictors of response to lofepramine were similar to overall predictors, i.e., psychic anxiety predicted responders whilst observed sadness, psychomotor retardation, lassitude, inability to feel and somatic complaints predicted nonresponders. In contrast, baseline weight loss predicted response to fluoxetine, whereas anxiety, reduced insight and a tendency to blame others significantly predicted nonresponse. Such findings have practical implications for the management of depressive illness. |
| Databáze: | OpenAIRE |
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