Oxidative stress and vein graft failure: a focus on NADH oxidase, nitric oxide and eicosanoids
| Autor: | Jamie Y. Jeremy, David C. Ellinsworth, Nilima Shukla, Helen Weaver |
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| Rok vydání: | 2011 |
| Předmět: |
Neointima
medicine.medical_specialty Vascular smooth muscle Isoprostane Prostacyclin Biology Nitric Oxide Nitric oxide chemistry.chemical_compound Multienzyme Complexes Internal medicine Drug Discovery medicine Animals Humans Platelet NADH NADPH Oxidoreductases Coronary Artery Bypass Enzyme Inhibitors Pharmacology NADPH oxidase Superoxide Thrombosis Oxidative Stress Endocrinology chemistry Biochemistry cardiovascular system biology.protein Eicosanoids medicine.drug |
| Zdroj: | Current opinion in pharmacology. 12(2) |
| ISSN: | 1471-4973 |
| Popis: | Recent interest has focused on superoxide and the upregulation of NADPH oxidase expression in the aetiology of vein graft failure. Implantation of saphenous vein grafts promotes upregulation of NADPH oxidase through a number of distinct interrelated mechanisms: (a) endothelial denudation, (b) factors released by adherent platelets, monocytes and neutrophils, (c) hypoxia and (d) altered prostacyclin (PGI(2)) and enhanced isoprostane formation. These, in turn, impact on neointima (NI) formation (vascular smooth muscle cell [VSMC] replication and migration) and metalloproteinase (MMP) expression, key events in vein graft thickening. NADPH oxidase in the aetiology of vein graft failure will be discussed in this review with particular reference to nitric oxide and eicosanoids and related drugs that inhibit its activity and expression. |
| Databáze: | OpenAIRE |
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