Alpha2‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses

Autor: Ulrik Grevstad, Anders Peder Højer Karlsen, Anja Geisler, Jakob Hessel Andersen, Ole Mathiesen, Pia Jaeger, Jørgen B. Dahl
Rok vydání: 2021
Předmět:
Zdroj: Andersen, J H, Karlsen, A, Geisler, A, Jæger, P, Grevstad, U, Dahl, J B & Mathiesen, O 2022, ' Alpha 2-receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta-analyses ', Acta Anaesthesiologica Scandinavica, vol. 66, no. 2, pp. 186-206 . https://doi.org/10.1111/aas.14002
ISSN: 1399-6576
0001-5172
DOI: 10.1111/aas.14002
Popis: Background: We review the efficacy and safety of dexmedetomidine and clonidine as perineural or systemic adjuvants for brachial plexus blocks (BPB). Methods: We included randomised controlled trials on upper limb surgery with BPBs in adults, comparing dexmedetomidine with clonidine or either drug with placebo. The primary outcome was duration of analgesia. Secondary outcomes included adverse and serious adverse events. The review was conducted using Cochrane standards, trial sequential analyses (TSA) and Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results: We included 101 trials with 6248 patients. Overall, duration of analgesia was prolonged with both clonidine (176 min [TSA adj. 95% CI: 118, 205, p
Databáze: OpenAIRE