Alpha2‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses
| Autor: | Ulrik Grevstad, Anders Peder Højer Karlsen, Anja Geisler, Jakob Hessel Andersen, Ole Mathiesen, Pia Jaeger, Jørgen B. Dahl |
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| Rok vydání: | 2021 |
| Předmět: |
Bradycardia
business.industry medicine.medical_treatment alpha-2-receptor agonists dexmedetomidine General Medicine Placebo nerve block Clonidine Anesthesiology and Pain Medicine adjuvants Anesthesia regional anaesthesia Nerve block Medicine medicine.symptom Dexmedetomidine clonidine business Adverse effect Lead (electronics) Brachial plexus medicine.drug |
| Zdroj: | Andersen, J H, Karlsen, A, Geisler, A, Jæger, P, Grevstad, U, Dahl, J B & Mathiesen, O 2022, ' Alpha 2-receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta-analyses ', Acta Anaesthesiologica Scandinavica, vol. 66, no. 2, pp. 186-206 . https://doi.org/10.1111/aas.14002 |
| ISSN: | 1399-6576 0001-5172 |
| Popis: | Background: We review the efficacy and safety of dexmedetomidine and clonidine as perineural or systemic adjuvants for brachial plexus blocks (BPB). Methods: We included randomised controlled trials on upper limb surgery with BPBs in adults, comparing dexmedetomidine with clonidine or either drug with placebo. The primary outcome was duration of analgesia. Secondary outcomes included adverse and serious adverse events. The review was conducted using Cochrane standards, trial sequential analyses (TSA) and Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results: We included 101 trials with 6248 patients. Overall, duration of analgesia was prolonged with both clonidine (176 min [TSA adj. 95% CI: 118, 205, p |
| Databáze: | OpenAIRE |
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