Ocular Graft-versus-Host Disease after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation
| Autor: | Pinki Prasad, Sunita Nathan, Saurabh Chhabra, Biljana Horn, Olaf Penack, Nosha Farhadfar, Maria Teresa Lupo Stanghellini, Minoo Battiwalla, Hien Liu, Debra Lynch Kelly, Mary E.D. Flowers, Michael Byrne, Bronwen E. Shaw, Seth J. Rotz, Neel S. Bhatt, Steven Z. Pavletic, John P. Galvin, Bipin N. Savani, Gregory A. Hale, Zachariah DeFilipp, Yoko Ogawa, Catherine J. Lee, Kristina Teär Fahnehjelm, Monica Alves, Hildegard Greinix, Vaibhav Agrawal, Nuria Valdés-Sanz, Ibrahim Ahmed, Jean A. Yared, Ami J. Shah, Igor Petriček, Grzegorz W. Basak, Luigi Berchicci, Scott D. Rowley, Erich Horn, Alicia Rovó, Hélène Schoemans, Yoshihiro Inamoto, Asim Ali, Rafael F. Duarte |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Eye Diseases Graft vs Host Disease Review Disease Eye Article 03 medical and health sciences 0302 clinical medicine Quality of life Risk Factors immune system diseases Transplant complications Humans Transplantation Homologous Medicine Intensive care medicine 610 Medicine & health Biology Societies Medical Bone Marrow Transplantation Transplantation Hematopoietic cell transplantation Hematopoietic cell business.industry Hematopoietic Stem Cell Transplantation Hematology Chronic graft-versus-host disease medicine.disease eye diseases Pathophysiology Europe Treatment Graft-versus-host disease surgical procedures operative Bone transplantation 030221 ophthalmology & optometry business 030215 immunology |
| Zdroj: | Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| DOI: | 10.7892/boris.123280 |
| Popis: | Ocular graft-versus-host disease (GVHD) occurs in more than one-half of patients who develop chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged morbidity that affects activities of daily living and quality of life. Here we provide an expert review of ocular GVHD in a collaboration between transplantation physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Recent updates in ocular GVHD regarding pathophysiology, preclinical models, risk factors, prevention, screening, diagnosis, response criteria, evaluation measures, and treatment are discussed. Ocular GVHD involves at least 3 biological processes: lacrimal gland dysfunction, meibomian gland dysfunction, and corneoconjunctival inflammation. Preclinical models have identified several novel pathogenic mechanisms, including the renin angiotensin system and endoplasmic reticulum stress signaling, which can be targeted by therapeutic agents. Numerous studies have identified reliable tests for establishing diagnosis and response assessment of ocular GVHD. The efficacy of systemic and topical treatment for ocular GVHD is summarized. It is important that all health professionals caring for HCT recipients have adequate knowledge of ocular GVHD to provide optimal care. ispartof: Biol Blood Marrow Transplant vol:25 issue:2 pages:e46-e54 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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