Estrogen receptor α and β are involved in the activation of lordosis behavior in estradiol-primed rats
| Autor: | Anne M. Etgen, Porfirio Gómora-Arrati, Marcos García-Juárez, Raymundo Domínguez-Ordoñez, Jeffrey D. Blaustein, Francisco Javier Lima-Hernández, Oscar González-Flores |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Lordosis Ovariectomy Posture Estrogen receptor Alpha (ethology) Estrous Cycle Rats Sprague-Dawley Sexual Behavior Animal 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Endocrinology Internal medicine medicine Animals Estrogen Receptor beta Estradiol Endocrine and Autonomic Systems Chemistry Estrogen Receptor alpha Antagonist PHTPP medicine.disease Lordosis behavior Rats 030104 developmental biology Facilitation Ovariectomized rat Female 030217 neurology & neurosurgery |
| Zdroj: | Hormones and Behavior. 86:1-7 |
| ISSN: | 0018-506X |
| DOI: | 10.1016/j.yhbeh.2016.08.010 |
| Popis: | The present study was designed to assess the participation of estrogen receptors alpha (ERα) and beta (ERβ) in the short-term facilitation of lordosis behavior in ovariectomized (ovx), estradiol (E2) primed rats. In experiment 1, dose response curves for PPT and DPN (ERα and ERβ agonists, respectively) facilitation of lordosis behavior (lordosis quotient and lordosis score) were established by infusing these agonists into the right lateral ventricle (icv) in female rats injected 40h previously with 5μg of E2 benzoate. PPT doses of 0.08 and 0.4ng produced high lordosis quotients starting at 30min and continuing at 120 and 240min post-injection. DPN induced high levels of lordosis behavior at all times tested. However, the intensity of lordosis induced by both agonists was weak. In experiment 2, we tested the involvement of each ER in facilitation of lordosis by icv infusion of MPP (ERα-selective antagonist) or PHTPP (ERβ-selective antagonist) prior to infusion of 2ng of free E2. Icv infusion of either MPP or PHTPP 30min before free E2 significantly depressed E2 facilitation of lordosis. The results suggest that both forms of ER are involved in the short-latency facilitation of lordosis behavior in E2-primed rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect