Cannabis use and striatal D2 receptor density in untreated first-episode psychosis: An in vivo SPECT study
| Autor: | Ignasi Carrió, Luis San, Gemma Safont, Belén Arranz, Valle Camacho, Eva Grasa, Maria Jose Escartí, A. Alonso, Iluminada Corripio, Maria J. Portella, Rosa Blanca Sauras, Rosa Dueñas, Enric Álvarez, Víctor Pérez, Marc Ferrer |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Pyrrolidines Adolescent (123)I-IBZM SPECT Statistics Nonparametric Young Adult In vivo Internal medicine Dopamine receptor D2 medicine Humans Prospective Studies Young adult Receptor Prospective cohort study Dopamine D2 receptors Biological Psychiatry Cannabis Tomography Emission-Computed Single-Photon Analysis of Variance biology Receptors Dopamine D2 medicine.disease biology.organism_classification Corpus Striatum Psychiatry and Mental health Endocrinology Psychotic Disorders Benzamides Dopamine Antagonists Female Analysis of variance Psychology Neuroscience |
| Zdroj: | SCHIZOPHRENIA RESEARCH r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0920-9964 |
| Popis: | The biological basis of the association between cannabis-induced dopamine dysregulation and psychosis remains poorly understood. This (123)I-IBZM SPECT study assessed striatal dopamine D2 receptor (D2R) binding in 37 untreated first-episode psychosis (FEP) subjects, and 18 healthy controls. The aim was to examine if there were differences between FEP subjects with (n=14) and without (n=23) cannabis use in uptake ratios in the D2R. Striatal/Frontal cortex (S/F) uptake ratios were obtained. Healthy controls showed the lowest D2R binding ratios. No differences were found in S/F ratios between users and non-users, suggesting similar dopaminergic mechanisms underlying psychotic symptoms in both groups. (C) 2011 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect