The delayed luminescence spectroscopy as tool to investigate the cytotoxic effect on human cancer cells of drug-loaded nanostructured lipid carrier
| Autor: | Giovanni Puglisi, Agata Scordino, M. Gulino, Claudia Carbone, Agatina Campisi, Francesco Musumeci, Roberta Bonfanti, Rosaria Grasso |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Nanostructured lipid carrier Glioblastoma multiforme medicine.disease Delayed luminescence Ferulic acid 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Mitochondrial respiratory chain chemistry Cell culture Cancer cell medicine Cancer research Cytotoxic T cell lipids (amino acids peptides and proteins) Mitochondrial respiratory chain complex I Cytotoxicity |
| Zdroj: | Biophotonics: Photonic Solutions for Better Health Care V. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.2227514 |
| Popis: | The first results concerning the possibility to use Delayed Luminescence spectroscopy to evaluate the in vitro induction of cytotoxic effects on human glioblastoma cells of nanostructured lipid carrier and drug-loaded nanostructured lipid carrier are showed in this contribution. We tested the effects of nanostructured lipid carrier, ferulic acid and ferulic acidloaded nanostructured lipid carrier on U-87MG cell line. The study seems to confirm the ability of Delayed Luminescence to be sensible indicator of alterations induced on functionality of the mitochondrial respiratory chain complex I in U-87MG cancer cells when treated with nanostructured lipid carriers. |
| Databáze: | OpenAIRE |
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