Protection Against Amebic Liver Abscess Formation in the Severe Combined Immunodeficient Mouse by Human Anti-Amebic Antibodies
| Autor: | Terry F. H. G. Jackson, Kari L. Braun, Samuel L. Stanley, Karl B. Seydel, Tonghai Zhang |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Ratón Antibodies Protozoan Virulence Mice SCID Lobosea Mice Entamoeba histolytica Virology medicine Animals Humans Abscess Immunodeficient Mouse biology Immunization Passive biology.organism_classification medicine.disease Infectious Diseases Immunology Liver Abscess Amebic biology.protein Protozoa Parasitology Antibody |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 55:330-332 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.1996.55.330 |
| Popis: | We have used serum from patients with amebic liver abscess to investigate the role of antibody in the prevention of invasive amebiasis using the severe combined immunodeficient (SCID) mouse model of Entamoeba histolytica infection. The SCID mice were passively immunized with serum or purified antibody from patients with amebic liver abscess 24 hr prior to the direct intrahepatic challenge with 106 virulent E. histolytica trophozoites. This treatment reduced the mean abscess size in these animals from 24.5% to 3.5% (P < 0.0001). These results demonstrate that human anti-amebic antibodies are capable of exerting a protective effect in an animal model of amebic liver abscess formation. |
| Databáze: | OpenAIRE |
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