Evidence for suppressor cells in Lewis rats' experimental allergic encephalomyelitis
| Autor: | D.‐H. Adda, R. Depieds, Evelyne Beraud |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Bordetella pertussis
Encephalomyelitis Autoimmune Experimental Time Factors Encephalomyelitis medicine.medical_treatment Immunology Spleen Thymus Gland Inhibitory postsynaptic potential law.invention law medicine Immunology and Allergy Animals Lymphocytes biology Immunity Immunization Passive medicine.disease biology.organism_classification Myelin basic protein Rats medicine.anatomical_structure biology.protein Suppressor Lymph Lymph Nodes Adjuvant |
| Zdroj: | European journal of immunology. 7(9) |
| ISSN: | 0014-2980 |
| Popis: | In this work we demonstrate a suppressive activity on the induction of experimental allergic encephalomyelitis (EAE) in Lewis rats, transferable to syngeneic animals, challenged with encephalitogenic mixture (myelin basic protein, complete Freund's adjuvant plus Bordetella pertussis organisms) 24 h later. This activity is probably effected by T cells and not by (an) inhibitory serum factor(s). The induction of this specific protection could be due to the penetration of the myelin basic protein antigen into the thymus where we first found suppressive cells. From the thymus, suppressor cells could then emigrate to spleen (on day 15) and to nondraining lymph nodes (on day 17). In the course of normal EAE in Lewis rats and especially at the time of self cure, this suppression is not demonstrated, but possible. |
| Databáze: | OpenAIRE |
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