The effects and mechanisms of the action of galangin on spatial memory in rats
| Autor: | Fatma Sultan Kilic, Sule Aydin, Bilgin Kaygisiz, Erol K, Setenay Oner, Engin Yildirim |
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| Rok vydání: | 2019 |
| Předmět: |
Economics and Econometrics
Scopolamine Morris water navigation task Mecamylamine Pharmacology 030226 pharmacology & pharmacy Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Muscarinic acetylcholine receptor Avoidance Learning Reaction Time Materials Chemistry Media Technology medicine Animals Donepezil Maze Learning Spatial Memory Flavonoids Forestry Rats Galangin Nicotinic agonist chemistry Cholinergic Cholinesterase Inhibitors 030217 neurology & neurosurgery Acetylcholine medicine.drug |
| Zdroj: | Bratislava Medical Journal. 120:881-886 |
| ISSN: | 1336-0345 |
| Popis: | Background Galangin, a flavonoid compound with acetylcholinesterase inhibitory activity, may improve cognitive functions by enhancing cholinergic transmission. Objectives We aimed to investigate the effects of galangin on spatial memory impairment in rats. Methods The effects of galangin (50 and 100 mg/kg) and reference anti-dementia drug donepezil (1mg/kg) administrations were examined on memory impairment induced by the muscarinic cholinergic receptor antagonist scopolamine or the nicotinic cholinergic receptor antagonist mecamylamine in the Morris water maze (MWM) test. Hippocampal acetylcholine concentrations were also determined. Results Galangin 50 and 100 mg/kg significantly decreased the mean distance to platform and increased the time spent in the escape platform quadrant in scopolamine-treated rats. Galangin 100 mg/kg significantly decreased the mean distance to platform and increased the time spent in the escape platform quadrant in mecamylamine-treated rats. The effects of galangin in the MWM were comparable with donepezil. Scopolamine and mecamylamine decreased acetylcholine concentrations, whereas galangin both alone and with mecamylamine or scopolamine administration increased acetylcholine concentrations. Conclusion Galangin improved memory impairment comparable to donepezil and nicotinic and muscarinic receptors may be involved in this effect. Galangin may be considered as a promising flavonoid in the prevention and treatment of memory impairment in Alzheimer's disease and other dementias (Fig. 7,Ref. 37). |
| Databáze: | OpenAIRE |
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