The endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses
| Autor: | Jean-Luc Vachiery, Anthony P. Davenport |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Hypertension Renal Endothelin A Receptor Antagonists Cardiologie et circulation Hypertension Pulmonary Disease Pharmacology Hypertension Pulmonary -- drug therapy -- etiology Receptor Endothelin A -- antagonists & inhibitors medicine Humans Endothelin system Receptor Pathological Kidney Lung Endothelin-1 Néphrologie - urologie business.industry Hypertension Renal -- drug therapy -- etiology medicine.anatomical_structure Endothelin-1 -- physiology cardiovascular system Pulmonary vasculature business Endothelin receptor |
| Zdroj: | European respiratory review, 18 (114 |
| ISSN: | 1600-0617 0905-9180 |
| DOI: | 10.1183/09059180.00005709 |
| Popis: | Endothelial cells regulate vascular tone largely by the actions of endothelin-1. Endothelin-1 is a potent vasoconstrictor, with effects that are dependent on the receptors to which it binds as well as their location. Endothelin-1 dysregulation is implicated in pathological conditions, including those of the pulmonary vasculature and the kidney. In this review, we describe the physiology and actions of endothelin-1 in lung and renal tissues and discuss therapies that disrupt these interactions in disease states. We provide an overview of the current clinical progress of these targeted agents and provide perspectives on the treatment of pulmonary and renal diseases with endothelin receptor antagonists. Journal Article Review SCOPUS: re.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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