B7 score and T cell infiltration stratify immune status in prostate cancer
Autor: | Wenli Cai, Jian Huang, Qiong Wang, Kewei Xu, Xiangyu Zhan, Kai Yao, Qianghua Zhou, Kaiwen Li, Wei Yao, Xingxing Zang, Hai Huang, Shirong Peng, Yiming Lai |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Immunology Prostate cancer Immune system Lymphocytes Tumor-Infiltrating Internal medicine Immunotherapy Biomarkers medicine Biomarkers Tumor Tumor Microenvironment Immunology and Allergy Humans RC254-282 Aged Retrospective Studies Pharmacology Aged 80 and over Immune status Tumor microenvironment business.industry T cell infiltration FOXP3 Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prostatic Neoplasms Middle Aged medicine.disease costimulatory and inhibitory T-cell receptors tumor biomarkers Molecular Medicine Immunohistochemistry business CD8 |
Zdroj: | Journal for Immunotherapy of Cancer Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021) |
ISSN: | 2051-1426 |
Popis: | BackgroundAlthough immune checkpoint inhibitors (ICIs), especially programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) axis blockers, exhibit prominent antitumor effects against numerous malignancies, their benefit for patients with prostate cancer (PCa) has been somewhat marginal. This study aimed to assess the feasibility of B7-H3 or HHLA2 as alternative immunotherapeutic targets in PCa.MethodsImmunohistochemistry was performed to evaluate the expression pattern of PD-L1, B7-H3 and HHLA2 and the infiltration of CD8+ and Foxp3+ lymphocytes in 239 PCa tissues from two independent cohorts. The correlations between B7-H3 and HHLA2 and clinicopathological features, including the presence of CD8+ and Foxp3+ tumor-infiltrating lymphocytes (TILs), were explored.ResultsHHLA2 expression was much higher than PD-L1 expression but lower than B7-H3 expression in PCa tissues. High expression of both B7-H3 and HHLA2 was significantly associated with higher Gleason score and tumor stage, lymph node metastasis and dismal overall survival (OS) and cancer-specific survival (CSS). Moreover, a high B7 score, defined as high B7-H3 expression and/or high HHLA2 expression, was an independent prognostic predictor for PCa. Of note, a high B7 score was negatively correlated with CD8+ TILs. Importantly, a new immune classification, based on the B7 score and CD8+ TILs, successfully stratified OS and CSS in PCa.ConclusionsBoth B7-H3 and HHLA2 have a critical impact on the immunosuppressive microenvironment, and the B7 score could be used as an independent prognostic factor for PCa. The B7 score combined with CD8+ TILs could be used as a new immune classification to stratify the risk of death, especially cancer-related death, for patients with PCa. These findings may provide insights that could improve response to immune-related comprehensive therapy for PCa in the future. |
Databáze: | OpenAIRE |
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