Current challenges and future perspectives of pharmacological testing using new approach methodologies
| Autor: | Ayano Satsuka, Yasunari Kanda, Kayoko Tsuji |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Coronavirus disease 2019 (COVID-19) SARS-CoV-2 Computer science COVID-19 Animal Alternative Animal Testing Alternatives Drug Development Drug development Risk analysis (engineering) SAFER Human longevity Animal Testing Alternative Evaluation methods Animals Humans Regulatory science Pandemics |
| Zdroj: | Folia Pharmacologica Japonica. 156:208-213 |
| ISSN: | 1347-8397 0015-5691 |
| DOI: | 10.1254/fpj.21020 |
| Popis: | The mission of regulatory science is to promote human longevity by providing safer and more effective drugs and ensuring human health. At present, various in vitro and in vivo evaluation methods are used for drug development, and no major problems have been observed. However, there is still room for improvement in terms of risk prediction in humans. Thus, new approaches and methodologies (NAMs) have recently been developed to predict adverse events in humans more accurately. Based on the animal alternative methods and the current COVID-19 pandemic, in vitro methods, such as human iPS cells, and computational approach are accelerated to improve the efficiency of drug development, ensure the patients' safety and speed up the review process. In this review, we would like to summarize the current status and future perspectives of pharmacological assay system using NAM in drug development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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