Light-Mediated Defluorosilylation of α-Trifluoromethyl Arylalkenes through Hydrogen Atom Transfer

Autor:	Fuyang Yue, Jianhua Liu, Henan Ma, Yuxiu Liu, Jianyang Dong, Qingmin Wang
Rok vydání:	2022
Předmět:	Organic Chemistry Silanes Physical and Theoretical Chemistry Oxidation-Reduction Biochemistry Catalysis Hydrogen
Zdroj:	Organic Letters. 24:4019-4023
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.2c01448
Popis:	Herein, we report a direct, light-mediated defluorosilylation protocol for converting α-trifluoromethyl arylalkenes and alkyl silanes into γ,γ-difluoroallylic compounds via a combination of photoredox catalysis and hydrogen atom transfer. The clean, convenient protocol can be scaled to the gram level, and its mild conditions make it very suitable for late-stage functionalization of complex natural products and drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e37ea89fe4f8cf8542ce7b0c74f2a31 https://doi.org/10.1021/acs.orglett.2c01448 Zobrazit plný text záznamu