Inflammasome-independent functions of NAIPs and NLRs in the intestinal epithelium
| Autor: | Kendle M. Maslowski, Gillian M Mackie, Lisa Scarfe |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
MAPK/ERK pathway
Immunology & Inflammation Stromal cell Inflammasomes NLR Proteins Biology Biochemistry Immune system inflammasome Host-Microbe Interactions medicine Animals Humans Intestinal Mucosa Receptor Review Articles innate immunity Cancer Innate immune system Pattern recognition receptor nod-like receptors Inflammasome Gastrointestinal Renal & Hepatic Systems Intestinal epithelium Neuronal Apoptosis-Inhibitory Protein epithelial cells Cell biology Colorectal Neoplasms host–pathogen interactions medicine.drug |
| Zdroj: | Biochemical Society Transactions |
| ISSN: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst20210365 |
| Popis: | The gut relies on the complex interaction between epithelial, stromal and immune cells to maintain gut health in the face of food particles and pathogens. Innate sensing by the intestinal epithelium is critical for maintaining epithelial barrier function and also orchestrating mucosal immune responses. Numerous innate pattern recognition receptors (PRRs) are involved in such sensing. In recent years, several Nucleotide-binding-domain and Leucine-rich repeat-containing receptors (NLRs) have been found to partake in pathogen or damage sensing while also being implicated in gut pathologies, such as colitis and colorectal cancer (CRC). Here, we discuss the current literature focusing on NLR family apoptosis inhibitory proteins (NAIPs) and other NLRs that have non-inflammasome roles in the gut. The mechanisms behind NLR-mediated protection often converges on similar signalling pathways, such as STAT3, MAPK and NFκB. Further understanding of how these NLRs contribute to the maintenance of gut homeostasis will be important for understanding gut pathologies and developing new therapies. |
| Databáze: | OpenAIRE |
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